![]() ![]() In addition, Au/BC hydrogel exhibited an excellent in vivo bone repair performance in a rabbit model of femoral defect, which was evidenced by the significant newly bone formation. ![]() Mechanism research showed that autophagy might be a potential pathway for Au/BC hydrogels-induced osteogenic differentiation of hBMSCs. The sustainable release of GNPs endowed the hydrogels with an outstanding biological activity in facilitating osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). The results showed that the increased feeding amounts of GNPs could remarkablly enhance the Au/BC hydrogels with better mechanical properties, higher porosity, larger surface area, and biocompatibility. The effects of GNPs on physicochemical properties of BC hydrogel and subsequently in vitro osteogenic differentiation and in vivo bone regeneration of Au/BC hydrogels were comprehensively investigated. In this study, gold nanoparticles (GNPs) with excellent osteogenic differentiation ability were incorporated into the network of BC hydrogel (Au/BC hydrogels) by the in-situ fermentation. However, the lack of osteogenic activity restricts its application. Bacterial cellulose (BC) possesses the desirable properties of biocompatibility, high porosity, high surface area and noticeable mechanical strength as a scaffold in bone tissue engineering. ![]()
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